|
KMID : 1100620160030030175
|
|
Clinical and Experimental Emergency Medicine
2016 Volume.3 No. 3 p.175 ~ p.180
|
|
|
Cardiac physiologic regulation of sub-type specific adrenergic receptors in transgenic mice overexpressing β1- and β2-adrenergic receptors
|
|
Kim ka-Eul
Tae Hyun-Jin
Petrashevskaya Natalia
Lee Jae-Chul
Ahn Ji-Hyeon
Park Joon-Ha
Kim In-Hye
Ohk Taek-Geun
Park Chan-Woo
Cho Jun-Hwi
Won Moo-Ho
|
|
|
Abstract
|
|
|
Objective:Combination of β1-adrenergic receptor (AR) blockade and β2-AR activation might be a potential novel therapy for treating heart failure. However, use of β-AR agonists and/or antagonists in the clinical setting is controversial because of the lack of information on cardiac inotropic or chronotropic regulation by AR signaling.
Methods:In this study, we performed hemodynamic evaluation by examining force frequency response (FFR), Frank-Starling relationship, and response to a non-selective β-AR agonist (isoproterenol) in hearts isolated from 6-month-old transgenic (TG) mice overexpressing β1- and β2-ARs (β1- and β2-AR TG mice, respectively).
Results:Cardiac physiologic consequences of β1- and β2-AR overexpression resulted in similar maximal response to isoproterenol and faster temporary decline of positive inotropic response in β2-AR TG mice. β1-AR TG mice showed a pronounced negative limb of FFR, whereas β2-AR TG mice showed high stimulation frequencies with low contractile depression during FFR. In contrast, Frank-Starling relationship was equally enhanced in both β1- and β2-AR TG mice.
Conclusion:Hemodynamic evaluation performed in the present showed a difference in β1- and β2-AR signaling, which may be due to the difference in the desensitization of β1- and β2-ARs.
|
|
|
KEYWORD
|
|
|
Adrenergic receptors, Transgenic mice, Isoproterenol, Inotropic, Chronotropic
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|